Prolific Machines is ushering in a new era of biotechnology with light. Our first-of-its-kind photomolecular platform delivers unprecedented control, precisely guiding cellular behavior when and where it matters most. Unlike existing tools used to control biology, our technology unlocks dynamic control over virtually any cellular function in any cell type. We're enabling partners to unlock robust efficiency, quality, reproducibility, and sustainability advantages across pharmaceuticals and therapeutic proteins. Prolific is supported by leading investors, including Bill Gates’s Breakthrough Energy Ventures, Mayfield and SOSV.
Help us create a brighter tomorrow with biology. We're looking for mission-driven, talented, and kind people to join our team.
About this Job
We are looking for a senior analytical scientist to lead therapeutic protein characterization across cell line development and process development. Should be updated to: We are looking for a senior analytical scientist to lead therapeutic protein characterization across cell line and process development.
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Responsibilities- Lead the development, optimization, and validation of HPLC and LC-MS methods for characterization of broad classes of recombinant therapeutic proteins.
- Lead experimentation to understand protein quality through cell line development, upstream and downstream process development.
- Execute, summarize and interpret routine and complex therapeutic protein characterizations.
- Qualify assays upholding highly rigorous standards for execution and documentation.
- Perform maintenance and troubleshoot analytical instrumentation (HPLCs, mass spectrometers).
- Author, review, approve and implement methods, protocols, validations and standard operating procedures. Ensure processes are followed in accordance with these standards.
- Act as a technical expert to internal and external client organizations with a focus on customer success.
- Identify and make investment cases for characterization tools that bring value to internal and external clients.
- Manage, mentor, and develop early career staff.
About You- Hold an advanced degree in Analytical Chemistry, Organic Chemistry, Biochemistry, Pharmaceutical Sciences, with 5+ years of industry experience. Candidates without advanced degrees but with similar industry experience are encouraged to apply.
- Have thorough knowledge and experience in protein therapeutic characterization and illustrated experience working a cell line development function to bring targets through discovery and scale up.
- Have developed LC-MS multi-attribute methods (MAM) in addition to assays characterizing other protein quality attributes (eg. Aggregation, charge variants, ect.).
- Qualify and validate assays upholding highly rigorous standards for execution and documentation.
- Have demonstrated outcome driven experience developing methods to support cell line development and Investigational New Drug submissions.
- Are highly motivated to deliver successful outcomes for internal and external clients.
- Excited to work with internal and external clients to deliver project excellence.
- Have strong communication skills and comfortable teaching and sharing knowledge at multiple levels of technical detail.
- Excited to educate, manage and mentor junior colleagues.
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$145,000 - $190,000 a year
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Diversity: We value diverse people, perspectives, and knowledge. To this end, we aim to foster a sense of belonging that enables everyone to bring their whole, authentic self to work everyday. We are committed to growing a diverse and inclusive team that encompasses all types of people. We believe this can only be achieved by acknowledging the ancestral, historic, and current systemic and communal inequities.
Location: The San Francisco Bay Area (Emeryville, CA)
Benefits: Outstanding Health, Vision & Dental Insurance (including full spouse coverage), at least one all-expense-paid team holiday per year, flexibility in schedule and unlimited vacation days. Free lunch every day!
